J. T. Knegtel: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

Don't use scam websites

1

Comparison of the Accuracy of Experimental and Predicted pKa Values of Basic and Acidic Compounds

Settimo, Luca, Bellman, Krista, Knegtel, Ronald M. A.

Journal:

Pharmaceutical Research

Year:

2014

Language:

english

File:

PDF, 834 KB

english, 2014

2

Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

Charrier, Jean-Damien, Durrant, Steven J., Golec, Julian M. C., Kay, David P., Knegtel, Ronald M. A., MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E., Pinder, Joanne L., Reaper, Phili

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.67 MB

english, 2011

3

Shifting of the double bond in methyl oleate during hydrogenation

J. T. Knegtel, C. Boelhouwer, M. Tels, H. I. Waterman

Journal:

Journal of the American Oil Chemists' Society

Year:

1957

Language:

english

File:

PDF, 245 KB

english, 1957

4

An Eimeria vaccine candidate appears to be lactate dehydrogenase; characterization and comparative analysis

SCHAAP, D., ARTS, G., KROEZE, J., NIESSEN, R., ROOSMALEN-VOS, S. V., SPREEUWENBERG, K., KUIPER, C. M., BEEK-VERHOEVEN, N. V. D., KOK, J. J., KNEGTEL, R. M. A., VERMEULEN, A. N.

Journal:

Year:

2004

Language:

english

File:

PDF, 478 KB

english, 2004

5

Rational design of 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of intra- and inter-molecular polar interactions of a new ataxia telangiectasia mutated and Rad3-related (ATR) kinase inhibitor

Knegtel, Ronald M. A., Charrier, Jean-Damien, Durrant, Steven John, Davis, Chris, O'Donnell, Michael, Storck, Pierre, MacCormick, Somhairle, Kay, David, Pinder, Joanne, Virani, Anisa, Twin, Heather, G

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 2.40 MB

english, 2019

6

Efficacy and selectivity in flexible database docking

Ronald M.A. Knegtel, Markus Wagener

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1999

Language:

english

File:

PDF, 383 KB

english, 1999

7

Similarity-driven flexible ligand docking

Xavier Fradera, Ronald M.A. Knegtel, Jordi Mestres

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2000

Language:

english

File:

PDF, 577 KB

english, 2000

8

A Method To Identify and Screen Libraries of Guests That Complex to a Synthetic Host

Menno R. de Jong, Ronald M. A. Knegtel, Peter D. J. Grootenhuis, Jurriaan Huskens, David N. Reinhoudt

Journal:

Angewandte Chemie

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

9

A Method To Identify and Screen Libraries of Guests That Complex to a Synthetic Host

Menno R. de Jong, Ronald M. A. Knegtel, Peter D. J. Grootenhuis, Jurriaan Huskens, David N. Reinhoudt

Journal:

Angewandte Chemie International Edition

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

10

Water-Soluble Molecular Capsules: Self-Assembly and Binding Properties

Francesca Corbellini, Ronald M. A. Knegtel, Peter D. J. Grootenhuis, Mercedes Crego-Calama, David N. Reinhoudt

Journal:

Chemistry - A European Journal

Year:

2005

Language:

english

File:

PDF, 435 KB

english, 2005

11

On the Mechanism of the Thermal Polymerization of Linseed Oil

Prof. Dr. Ir. C. Boelhouwer, Dr. Ir. J. Th. Knegtel, Prof. Ir. M. Tels

Journal:

European Journal of Lipid Science and Technology

Year:

1967

Language:

english

File:

PDF, 440 KB

english, 1967

12

A Role for Hydration in Interleukin-2 Inducible T Cell Kinase (Itk) Selectivity

Ronald M. A. Knegtel, Daniel D. Robinson

Journal:

Molecular Informatics

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

13

Computer-Assisted Assignment of Homonuclear 3D NMR Spectra of Proteins. Application to Pike Parvalbumin III

G.J. Kleywegt, G.W. Vuister, A. Padilla, R.M.A. Knegtel, R. Boelens, R. Kaptein

Journal:

Journal of Magnetic Resonance, Series B

Year:

1993

File:

PDF, 1.02 MB

1993

14

The discovery of the potent aurora inhibitor MK-0457 (VX-680)

David Bebbington, Hayley Binch, Jean-Damien Charrier, Simon Everitt, Damien Fraysse, Julian Golec, David Kay, Ronald Knegtel, Chau Mak, Francesca Mazzei, Andrew Miller, Michael Mortimore, Michael O’Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.08 MB

english, 2009

15

Practical evaluation of comparative modelling and threading methods

M.J.L Schoonman, R.M.A Knegtel, P.D.J Grootenhuis

Journal:

Computers & Chemistry

Year:

1998

Language:

english

File:

PDF, 1.28 MB

english, 1998

16

Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor

Patricia S. Caldera, Zhonghua Yu, Ronald M.A. Knegtel, Fiona McPhee, Alma L. Burlingame, Charles S. Craik, Irwin D. Kuntz, Paul R. Ortiz de Montellano

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 711 KB

english, 1997

17

A model for the LexA repressor DNA complex

Ronald M. A. Knegtel, Rasmus H. Fogh, Rolf Boelens, Robert Kaptein, Gunnar Ottleben, Heinz Rüterjans, Pascal Dumoulin, Manfred Schnarr

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1995

Language:

english

File:

PDF, 1.08 MB

english, 1995

18

The solution structure of the human retinoic acid receptor-β DNA-binding domain

R. M. A. Knegtel, M. Katahira, J. G. Schilthuis, A. M. J. J. Bonvin, R. Boelens, D. Eib, P. T. Saag, R. Kaptein

Journal:

Journal of Biomolecular NMR

Year:

1993

Language:

english

File:

PDF, 2.52 MB

english, 1993

19

Coping strategies in farmed African catfish Clarias gariepinus. Does it affect their welfare?

P. G. Van de Nieuwegiessen, N. M. Ramli, B. P. F. J. M. Knegtel, J. A. J. Verreth, J. W. Schrama

Journal:

Journal of Fish Biology

Year:

2010

Language:

english

File:

PDF, 548 KB

english, 2010

20

Comparison of two implementations of the incremental construction algorithm in flexible docking of thrombin inhibitors

Ronald M.A. Knegtel, Denis M. Bayada, Richard A. Engh, Wolfgang von der Saal, Vincent J. van Geerestein, Peter D.J. Grootenhuis

Journal:

Journal of Computer-Aided Molecular Design

Year:

1999

Language:

english

File:

PDF, 161 KB

english, 1999

21

Similarity versus docking in 3D virtual screening

Jordi Mestres, Ronald M.A. Knegtel

Journal:

Perspectives in Drug Discovery and Design

Year:

2000

Language:

english

File:

PDF, 136 KB

english, 2000

22

The solution structure of a monomeric insulin : A two-dimensional 1H-NMR study of des-(B26–B30)-insulin in combination with distance geometry and restrained molecular dynamics

Ronald M. A. KNEGTEL, Rolf BOELENS, Maria Luisa GANADU, Robert KAPTEIN

Journal:

Year:

1991

Language:

english

File:

PDF, 1007 KB

english, 1991

23

Heteronuclear 113Cd-1H NMR Study of Metal Coordination in the Human Retinoic Acid Receptor-β DNA Binding Domain

R.M.A. Knegtel, R. Boelens, M.L. Ganadu, A.V.E. George, P.T. Vandersaag, R. Kaptein

Journal:

Biochemical and Biophysical Research Communications

Year:

1993

File:

PDF, 307 KB

1993

24

Crystal Structure at 2.3 Å Resolution and Revised Nucleotide Sequence of the Thermostable Cyclodextrin Glycosyltransferase fromThermoanaerobacterium thermosulfurigenesEM1

Ronald M.A. Knegtel, Richèle D. Wind, Henriëtte J. Rozeboom, Kor H. Kalk, Reinetta M. Buitelaar, Lubbert Dijkhuizen, Bauke W. Dijkstra

Journal:

Journal of Molecular Biology

Year:

1996

Language:

english

File:

PDF, 1.01 MB

english, 1996

25

Molecular docking to ensembles of protein structures

Ronald M.A Knegtel, Irwin D Kuntz, C.M Oshiro

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 759 KB

english, 1997

26

Site-directed mutagenesis of glutamate 317 of bovine α-1,3Galactosyltransferase and its effect on enzyme activity: Implications for reaction mechanism

Patricia Molina, Ronald M.A. Knegtel, Bruce A. Macher

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2007

Language:

english

File:

PDF, 614 KB

english, 2007

27

Structure-based optimization of aminopyridines as PKCθ inhibitors

Juan-Miguel Jimenez, Christopher Davis, Dean Boyall, Damien Fraysse, Ronald Knegtel, Luca Settimo, Stephen Young, Claire Bolton, Peter Chiu, Adam Curnock, Richele Rasmussen, Adam Tanner, Ian Ager

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 839 KB

english, 2012

28

MONTY: a Monte Carlo approach to protein-DNA recognition

Ronald M.A. Knegtel, J. Antoon, C. Rullmann, Rolf Boelens, Robert Kaptein

Journal:

Journal of Molecular Biology

Year:

1994

Language:

english

File:

PDF, 778 KB

english, 1994

29

NMR Studies of the Human Retinoic Acid Receptor-β DNA-Binding Domain : Metal Coordination and Three-Dimensional Structure

R. M. A. KNEGTEL, R. BOELENS, M. L. GANADU, A. V. E. GEORGE, M. KATAHIRA, A. M. J. J. BONVIN, D. EIB, P. T. VAN DER SAAG, R. KAPTEIN

Journal:

Annals of the New York Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 679 KB

english, 1993

30

Advances in the design of ITK inhibitors

Charrier, Jean-Damien, Knegtel, Ronald MA

Journal:

Expert Opinion on Drug Discovery

Year:

2013

Language:

english

File:

PDF, 1.47 MB

english, 2013

31

Kinetic and mechanistic characterisation of Choline Kinase-α

Hudson, Catherine S., Knegtel, Ronald M., Brown, Kieron, Charlton, Peter A., Pollard, John R.

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2013

Language:

english

File:

PDF, 1.11 MB

english, 2013

32

Structure of Cyclodextrin Glycosyltransferase Complexed with a Maltononaose Inhibitor at 2.6 Å Resolution. Implications for Product Specificity †,‡

Strokopytov, Boris, Knegtel, Ronald M. A., Penninga, Dirk, Rozeboom, Henriëtte J., Kalk, Kor H., Dijkhuizen, Lubbert, Dijkstra, Bauke W.

Journal:

Year:

1996

Language:

english

File:

PDF, 380 KB

english, 1996

33

Homo- and heteronuclear NMR studies of the human retinoic acid receptor .beta. DNA-binding domain: sequential assignments and identification of secondary structure elements

Katahira, M., Knegtel, R. M. A., Boelens, R., Eib, D., Schilthuis, J. G., Van der Saag, P. T., Kaptein, R.

Journal:

Year:

1992

Language:

english

File:

PDF, 792 KB

english, 1992

34

Rational Design of Novel Antimicrobials: Blocking Purine Salvage in a Parasitic Protozoan †

Somoza, John R., Skillman,, A. Geoffrey, Munagala, Narsimha R., Oshiro, C. M., Knegtel, Ronald M. A., Mpoke, Solomon, Fletterick, Robert J., Kuntz, Irwin D., Wang, Ching C.

Journal:

Year:

1998

Language:

english

File:

PDF, 104 KB

english, 1998

35

Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors

Charrier, Jean-Damien, Miller, Andrew, Kay, David P., Brenchley, Guy, Twin, Heather C., Collier, Philip N., Ramaya, Sharn, Keily, Shazia B., Durrant, Steven J., Knegtel, Ronald M. A., Tanner, Adam J.,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.31 MB

english, 2011

36

Structure of the LexA Repressor−DNA Complex Probed by Affinity Cleavage and Affinity Photo-Cross-Linking †

Dumoulin, Pascal, Ebright, Richard H., Knegtel, Ronald, Kaptein, Robert, Granger-Schnarr, Michèle, Schnarr, Manfred

Journal:

Year:

1996

Language:

english

File:

PDF, 469 KB

english, 1996

37

Monte Carlo docking of protein-DNA complexes: incorporation of DNA flexibility and experimental data

Knegtel, Ronald M.A, Boelens, Rolf, Kaptein, Robert

Journal:

Protein Engineering Design and Selection

Year:

1994

Language:

english

File:

PDF, 4.42 MB

english, 1994

38

The Raw Starch Binding Domain of Cyclodextrin Glycosyltransferase from Bacillus circulans Strain 251

Penninga, D., van der Veen, B. A., Knegtel, R. M. A., van Hijum, S. A. F. T., Rozeboom, H. J., Kalk, K. H., Dijkstra, B. W., Dijkhuizen, L.

Journal:

Journal of Biological Chemistry

Year:

1996

Language:

english

File:

PDF, 916 KB

english, 1996

39

Fucosyltransferases: structure/function studies

de Vries, T., Knegtel, R. M.A., Holmes, E. H., Macher, B. A.

Journal:

Year:

2001

Language:

english

File:

PDF, 745 KB

english, 2001

40

Site-specific Fucosylation of Sialylated Polylactosamines by 1,3/4-Fucosyltransferases-V and -VI Is Defined by Amino Acids Near the N Terminus of the Catalytic Domain

Shetterly, S., Jost, F., Watson, S. R., Knegtel, R., Macher, B. A., Holmes, E. H.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 1.11 MB

english, 2007

41

Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures

de Vries, T., Yen, T.-Y., Joshi, R. K., Storm, J., van den Eijnden, D. H., Knegtel, R. M. A., Bunschoten, H., Joziasse, D. H., Macher, B. A.

Journal:

Year:

2001

Language:

english

File:

PDF, 329 KB

english, 2001

42

Sequence annotation of nuclear receptor ligand-binding domains by automated homology modeling

Francoijs, C.J. J., Klomp, J. P.G., Knegtel, R. M.A.

Journal:

Protein Engineering Design and Selection

Year:

2000

Language:

english

File:

PDF, 81 KB

english, 2000

43

Rational design of 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of intra- and inter-molecular polar interactions of a new ataxia telangiectasia mutated and Rad3-related (ATR) kinase inhibitor

Knegtel, Ronald M. A., Charrier, Jean-Damien, Durrant, Steven John, Davis, Chris, O'Donnell, Michael, Storck, Pierre, MacCormick, Somhairle, Kay, David, Pinder, Joanne, Virani, Anisa, Twin, Heather, G

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 2.40 MB

2019

44

Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) that Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis

Collier, Philip N, Twin, Heather C., Knegtel, Ronald M. A., Boyall, Dean, Brenchley, Guy, Davis, Christopher J., Keily, Shazia, Mak, Chau, Miller, Andrew, Pierard, Françoise, Settimo, Luca, Bolton, Cl

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

Language:

english

File:

PDF, 539 KB

english, 2019